Circular Dichroism and Secondary Structure of Proteins Essay Example for Free

Circular Dichroism and Secondary Structure of Proteins Essay Proteins are vital to an organism life; they are involved in nearly all cellular functions. It is an essential part of enzymes, the cellular membrane, active transport, protein synthesis and wound healing. Because one relies so heavily upon proteins and its function the structure of proteins is also very important. â€Å"The way a protein will fold over its self-determines how it interacts with other chemicals in its proximity, primarily because of different attractive forces being subjected at specific angles from certain amino acids on the protein’s primary structure and the final shape in the tertiary and quandary structure (Circular dichroism ). † The structure of proteins can range from simple to complex molecules. Proteins may consist of a primary, secondary, tertiary, and quaternary structure. The secondary structure consists of hydrogen bonds which join amide and carboxyl groups. These bonds aren’t far from the backbone of proteins. This structure is capable of structures such as alpha helicies, beta sheets, and beta turns (Jim, 2007). The physical, secondary structure is important because it helps in determining the activity of a protein. Circular Dichrosim spectroscopy has been identified as prevalent application used in structural biology in determining whether a protein is folded, characterizing its secondary structure, tertiary structure, and the structural family along with other uses as well (Circular dichroism ). Circular dichroism, CD spectroscopy has defined a form of light absorption spectroscopy. It measures the difference in the absorption of circular polarized light by a substance on the right and left. The secondary structure of a protein can be analyzed between the spectrum of approximately 260 and 180 nm. Estimates of secondary proteins can be compared to X-ray crystallography or NMR (Kelly, Jess, C., 2005).The structures identified in this spectrum are the alpha helix, parallel and antiparallel beta sheet, and turns (Berndt, 1996). The only drawback with CD is that even with the implied spectrum, it has been found that there is no exact standard reference spectrum for a pure secondary structure. Synthetic homopolypeptides used to obtain reference spectra are in general, poor models for the secondary structures found in proteins (Berndt, 1996). The CD signal reflect the entire molecular population; it can determines how much of a certain structure and protein contains. It cannot determine the specific residues involved in the alpha-helical portion. In Circular Dichroism a linear polarized light passes through a optically active sample of a protein. This protein has a different absorbance for components. The amplitude of the stronger absorbed component will smaller than that of the less absorbed component. A projection is created of the resulting amplitude. The result is no longer a linear line but and ellipse (PARTHASARATHY, 1985). Different analyses have been developed to help with various contributions that arise from the different types of secondary structures present in a single molecule. The use of reference spectra have been created from known protein structures to help find the overall and secondary structure of unknown proteins (Whitmore A., 2007). â€Å"Recently a new reference dataset of SRCD spectra of proteins of known structure, designed to cover secondary structure and fold space (Berndt, 1996).† Works Cited Berndt, K. D. (1996, May 31). 4.2.1 Circular dichroism spectroscopy. Retrieved October 02, 2012, from 4.2.1 Circular dichroism spectroscopy Circular dichroism . (n.d.). Retrieved October 02, 2012, from APlab: http://www.ap-lab.com/circular_dichroism.htm Jim, C. (2007, August). The Structure of Proteins. Retrieved October 02, 2012, from Chemguide: http://www.chemguide.co.uk/organicprops/aminoacids/proteinstruct.html Kelly, S. M., Jess, T. J., C., P. N. (2005). How to study proteins by circular dichroism. Biochimica et Biophysica Acta 1751, 119 – 139. PARTHASARATHY, M. (1985). Protein secondary structure from circular dichroism spectra. Proc. Int. Symp. Biomol. Struct. Interactions, 141-149. Whitmore, L., A., W. B. (2007). Protein Secondary Structure Analyses from Circular Dichroism. Biopolymers, 392-400. `

Spinoza And Free Will Essay -- essays research papers

  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  There are many great philosophical ideas and questions that are known and of course unknown. One of the questions that really enticed my interest was the question of whether or not we have free will. I myself was once a believer of people having free will and doing what I want was my choice and my choice alone. However, after careful consideration and lectures I have been reversed in how I believe in free will. Is there any free will though? Many people would say yes there is and of course there are some who believe that free will is a fallacy and not to be believed. Whether or not there is free will is yet to be determined but what we have to go on and by is from philosophers and every person who has their two cents to fill in. In this discussion of philosophy there will be points made for and against the establishment of free will and basis for judgement of free will exists or not.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Spinoza, Paul, Augustine, Luther have all grappled with this question of free will for many years. What has been said goes to a religious side. Which has been believed of an omnipotent God who will preordain who would be saved and who would be lost. In the simple but complex question in the book of whether or not you slept in late or not, and has been said that God knew you would. With the explanation of the book in its words go as follows; â€Å"This...

Note taking Content Analysis

My research study is completely based on secondary resources because I have used various books and case laws to support the argument and they are a rich source of citation in legal projects. 1) Library Research a) Analysis of Historical records b) Analysis of documents c) Reference and Abstract Guides d) Note taking Content Analysis 2) Researching through the Internet E-article B) Relevance Of The Topic / Scope And Purpose The project aims to give a brief overview of the corruption and bribery practices undertaken by the public servants and the Indian laws dealing with the problem. The main law, I. . The Prevention of Corruption Act 1988, is discussed in brief and the provisions pertaining to seizure of ill-gotten wealth and asset reinstatement have also been discussed. The problems and challenges faced by the country in fighting these challenges have also been highlighted. C) Research Questions: 0 What is meant by the term economic offences? 0 What are the various types of economic offences? 0 What is the need of having Economic Offences Wing in India? 0 Sectors most vulnerable to corruption and bribery practices 0 What exactly leads to corruption and bribery practices, undertaken by people? What are the various causes of corruption? D) Limitation of the Research: The research study carries with itself a few limitations, like, as it's restricted to the secondary research so, the quality of research is affected as the origins of the information maybe questionable. Secondary research never meets the specific needs of researcher because all those information, data, statistics have already been generated. Hence, I would suggest further researchers to critically evaluate and validate the reliability and credibility of the information gathered. CHAPTER II – INTRODUCTIONThe high potential of the domestic market which is driven by Indian's emerging middle class, cost competitiveness and its large talent pool continue to make our country one of the most preferre d destination for investors and businessmen. Despite the such as the United States, India remained stable. In fact, it registered growth in the foreign direct investment (FED)I . It garnered more than 110 % in the areas of telecommunication and chemicals, with a percentage of 103 and 227 respectively. L Now the question that arises is that, in spite of India being economically sound why re we still in a state of poverty?Why majority of our population still dowels in slum area? Why each day lots of children die out of hunger/ starvation? The most probable answer to these questions are the rooted instances of corruption and bribery in our system. The schemes/policies which are announced by the government each year in order to benefit the unprivileged are not being availed by them since there are certain loopholes in the system and the people who are not entitled to them take undue advantage and enjoy them. Corruption real or perceived is having a detrimental effect on our economy.On o ne and it is forcing investors to rethink about their investment in India and on the other hand, it is distorting the function of free and fair market and creating a state of unfair competition. ORIGIN/ HISTORICAL PERSPECTIVE: The instances of corruption and bribery form a part of our system from a long time. Take for an instances that an early stage of world war II, the Government of India realized that the vast increase in expenditure for war efforts had provided opportunities to both government officials and non-officials, for 1 www. Antistatic. Com indulging in bribery and corruption at the cost of public and the government. It was felt that the police and other law enforcement agencies under the state government were not in a situation to cope up with the situation. An executive order was therefore passed by the Government of India in 1941, setting up the Special police establishment under a DIG in then department of war with mandate to investigate cases of bribery and corrupti on in transaction with which war and supply department of the Government of India was concerned.Corruption has been blamed for the failures of certain developing countries to develop, and recent empirical research confirms a link between higher perceived corruption and lower investment and growth. What is Corruption? Corruption is a result of weak state management and exists when individuals or organizations have monopoly power over a good or service, discretion over making decisions, limited or no accountability, and low level of income.The frequently cited World Bank definition of corruption is the abuse of public office for private gain (World Bank 1997). Corruption not only affects broad macroeconomic variables, such as growth, and investment, but also income distribution. It has been further explained by United Nation Development Program (1997) that corruption increases poverty by creating incentives for higher investment in capital-intensive projects and lower investment in el aborateness's projects. Thus corruption causes poverty and income inequality.WHAT IS BRIBERY? Bribery is an act of giving money or gift that alters the behavior of the recipient, where the gift is of a dishonest nature. Bribery constitutes a crime and is defined by Black law dictionary, as the offering, giving, receiving, or soliciting of any item of value to influence the actions of an official or other person in charge of a public or legal duty. Offering a discount or a full or partial refund to all purchasers of the same kind, quality and quantity of product or service, is a legal rebate, and is not bribery.For example, it is legal for a 7 employee of a Public Utilities Commission involved in electric rate regulation to accept a rebate on electric service that reduces their cost for electricity, when the rebate is available to other residential electric customers. If the rebate was done to influence them to look favorably on the electric utility's rate increase applications, howe ver, that would be bribery, and unlawful. Now both corruption and bribery form a part of economic offences. Since they have decision of potential investors but they hamper the growth of free and fair market practices.Special Acts notified under section 3 of DOSE Act mainly pertaining to serious frauds in Banks, Stock Exchanges, Financial institutions, Joint Stock Companies, Public Limited Companies, misappropriation of public funds, criminal breach of trust, violation of Foreign Exchange Regulation Act, Customs Act, IMMIX Laws, counterfeiting of currency, narcotics, drug trafficking, arms peddling and offences related to antiquities, adulteration, black marketing etc. Www. Sibylline. Com 8 However after the Securities and Stock Exchange scam of 1992, a need was felt for strengthening and expanding the Economic Offences Wing of CB.The reorganization of the OWE was sanctioned by the Government of India vide DIP&T Letter No. 201123/92-AVID-II, dated July 22, 1994 and September 22, 1994 and a full-fledged Economic Offences Division came into existence , vide Order No. 4. 6/86-OLD, dated November 26, 1994. WORKING OF THE ECONOMIC OFFENCE WING:4 The Economic Offences Division is headed by a Special Director/Additional Director and it consists of four Zones. Each Zone is headed by a Joint Director. Every Zone has two or three Regions each headed by a DIG. Each Region comprises of two or three Branches headed by Superintendents of Police.Out of the four Zones of Economic Offence Division, one of the Zones deals exclusively with large and complicated security and bank frauds. This zone is also known as Banking Securities Fraud Cell (BASS). The other three Zones take up the investigation (of various types of Economic Offences, in general. The Court trials of the cases charge sheeted by the various OWE Branches are also conducted by the respective Branches. The economic offences taken up for investigation by Branches are usually cases of complicated and intricate nature in which PC offences, as also offences under arioso Central Acts are alleged to have been committed.The investigations usually involve collection and scrutiny of voluminous documents from banks as also from various Central/State Government departments. Many a time, investigation is www. CB. Nice. In/about/about. PH 9 Various type of economic offences Bank fraud Insider trading Money laundering Walla Betting and match fixing BANK FRAUD: bank fraud is the use of illegal means to secure money, assets or other property owned or held by a financial institute or to obtain money from depositors by redundantly posing as a bank or some other financial institute.People who are willing to deceive other people and obtain their money or assets through illegal means may set up companies or create websites with names that might sound similar to the existing banks, or even assume titles conferring notability to themselves for plausibility, then flee with the deposited funds. INSIDER TRADING : insid er trading is a trading of a company's shares or other securities by directors, employees, executives or other authorities of a company that have to access the material, non-public information of the company.Whereby ‘Material information' means any information that can cause a change in the stock prices. Not only does illegal insider trading give an unfair advantage to those who resort to it, but also leads to a loss for the masses, and enormous gains for a few. This makes investors refrain from investing in the capital market as they lose their faith in the system. Also since the investors are the lifeline of these companies, since they provide capital to facilitate liquidity, the economy is affected as a whole.Insider trading exists in India due to multiple reasons such as shortage of investigative powers and tools of SIB, as they cannot use wire tapes, and merely search phone records. Also, eighteen the overburdened Indian courts lead to delays in cases or the punishment is too light even if one is found guilty. 10 obtained money, typically by the means of transfers involving foreign bank or legitimate businesses. It is the process by which large amount of illegally obtained money is given the appearance of having originated from a legitimate source. WALLA: one of the most practiced illegal activity is Walla.It is a transfer of money without physical movement of money. Walla is an Arabic word which means ‘Transfer'. This process is most prominent in South Asia. It completely takes place on honor system and no promissory instrument is involved. Usually the Walla Walla charge a commission of 0. 5 % – 1% for domestic transfer but when the transfer is international along with the commission they also earn profit by bypassing the currency exchange rates. 5 SPOT FIXING: It refers to an illegal activity in a sport where a specific part of a game is fixed.

Is Treating Homosexuality Ethical and Effective - 1940 Words

Homosexuality reorientation therapy is a controversial topic. Its effectiveness as well as the ethics involved stir up much debate. Since homosexuality is not an illness, The American Psychological Association reiterated the ‘long-standing official position that homosexuality and bisexuality are not mental disorders, (APA, 1998) (Slife, 2004), can it be treated? If it can, how, and under what circumstances it should be used, are important questions. Before discussing treatment, original orientation must be understood. Kinsey suggests that sexual orientation ranges along a continuum from exclusively homosexual (Kinsey rating 6) to exclusively heterosexual (Kinsey rating0) (House and Miller, 1997) (Slife, 2004). There are†¦show more content†¦These therapists often encourage that women take cooking or sewing classes and men to participate in team sports or groups to develop their true feminine or masculine identity (Evans, 2003). If one can embrace these identities, then it is believed that they will have healthy sexual lives and views. Therapists and Psychologists who practice these therapies argue that clients who want to change should not be told that they cannot; thus, it is not certain that they are settled on a fixed trait (Slife, 2004). Some patients who enter therapy with a wide range of unhappy constructions and attitudes toward their sexuality, learn to redefine themselves and their sexuality, and thus enhance their potential (Nicolosi, 2005). Conversion therapy is a term used to designate an array of counseling techniques designed to effect a shift in sexual preference (Throckmorton, 2005). Reports of patients seem to show positive results from treatment, even if there is no change in sexual orientation (Slife, 2004). Those who request conversion therapy often do so because of conflict between their homosexual feelings and the culture surrounding them. Counselors who practice conversion therapy attempt to understand the cultural background of clients who have deep conflicts over sexual impulses and deeply held moral convictions. Counselors are required to inform clients of the purposes, goals, techniques, procedures, limitations andShow MoreRelatedThe Ethics Of The Field Of Healthcare1419 Words   |  6 PagesAccording to Ekland-Olson, the sociological and clinical process is crucial in devising a moral ground for decision-making (111). The historical and medical perspectives of these issues can assist in shaping eth ical decision-making. Healthcare practitioners are continually facing ethical dilemmas concerning a broad set of issues that arise in the clinical setting. 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